What is your opinion on using a serger to sew those long wof strips together? It would go so much faster than with a sewing machine but would it hold up as well?

The bulk of the seam would be greater with all that thread and an accurate scant 1/4" would be a challenge.

I don't have a serger .... but would wonder what you would accomplish? Wouldn't you use more thread? and have a bulkier seam? Also, can you maintain an even 1/4" seam as easily?

And it would depend on what you will be doing with it, are you rotary cutting it down into blocks, like 4 or 9 patch-anything, really? I find that the serged seam ends ravel when blunt cut, like rotary cut. quilters need the seam allowance to stay sewed, since we are only making a 1/4" seam.

Eleanor Burns showed it on one of her videos, but I believe she only used three threads.

I appreciate your input. I'm doing a rail fence for my GD's birthday and as I was sewing I was thinking how this could go together faster. This is a cute pattern:
http://www.mccallsquilting.com/conte...ssRoadsWEB.pdf

Cute pattern. I did a flannel rail fence and serged it. It turned out nice, but it is quite thick with the serged seams and flannel. Works well for me because I don't have heat in my bedrooms and this will be warm.