I am a lefty. I use left handed scissors. I Switch the blade in a rotary cutter so it works for left handed use. I adjust the way things are cut . For example you may get instructions to cut a folded fat quarter starting at the left working to the right . That is awkward for me and I do it from Right to left. That is all I can think of but there may be other thing I do so automatic that I am not aware that I do it.