Practice and see what works for you ...I tend to work vertical whereas someone else likes horizontal.
That said, I suggest starting small (pillow, baby quilt, etc) to see what works.
Someone else mentioned they like the gloves. I bought a pair and can't stand to use them....Just remember to not get your fingers too close to the needle/foot! It hurts to have a needle go through your fingernail!
It truly is about personal preference and how it works best for you!