I've used homespuns quite a bit and pretty much treat them like any other quilting suitable fabric and often mix them in with my scrap quilts. I do admit that I am more likely to combine them with a standard weave than go all homespun, but I think that's mostly me. I do prewash and then crisp iron, but I personally don't use starch.
This is a top I haven't finished quilting. It was meant for my husband's father but he passed before I got the top quilted...