I have found that wetting the spots, then putting Blue Dawn, spraying with peroxide and adding baking soda to the spots to make a paste, slightly rubbing in with an old toothbrush and let sit for an hour or longer takes out every spot that I have encountered, including permanent marker, ink, oil, cow manure and grease. I wash it in wash machine with regular detergent in cold water. It may take a couple of times, but it will come out. Good luck!