My recommendation is to fussy cut if appropriate. If the print just doesn't lead itself to fuzzy cutting, using the little square as a color block can be a solution or an image can be just peeking our from the seam. I know some of my birthday candies and some Christmas blocks were fussy cut to get an image in the center of the square. Others were just cut to highlight the dominate color.
I attached a photo of a little quilt for a stuffed bear. I used 36 of my 2.5s. The bear, quilt and other items will be donated to the Samaritan's Purse Christmas Child project my church is participating in again this year. What an easy way to bring a smile to a child!