Yes, it is possible. I have a Juki 2200 QVP Mini which is a straight stitch only machine with a large throat. I quilt all my own quilts on it. You don't have to have a longarm to quilt your own quilts. Before I had the Juki, I did a king size quilt on my old Bernina with a tiny throat space. I used Marti Mitchell's Quilting in Sections technique to make it more manageable.