I love my Accuquilt (Studio II). I also occasionally cut by hand, but cutting using die cuts is so much faster. I line up the grain most of the time and have no trouble sewing things. I get great accurate cuts with the die cutter and usually get accurate cuts with rotary cutting as well using a variety of brands of rulers. The advantage of die cutting to me is faster cutting so I can piece more. Biggest downside is the fixed size of the die cuts. Usually I adjust blocks to fit the size dies I have, if possible. If not, I hand cut.
My trouble is the AQ is sooooocurate there is nothing left to trim so you have to make sure your seams are accurate. No cutting big and trimming to size with AQ,
