I have and I find it harder to quilt as it slips around and also it is heavy. I much prefer it as backing and use normally batting if sandwiching.

I have used fleece as backing and batting without any trouble. Quilts were quilted on a gracie pro frame. I was just careful not to stretch the fleece. My oldest grandson(7) requested a "warm" quilt, he says cotton on the back is cold!

I agree with your GS cotton is cold! that is why I am trying to work in the fleece somewhere. :-)

IMHO - fleece is nice for backing, but I only use for baby quilts (about 4X6 or width of fleece). Then I make a cotton block designs on front. I've also used the Fablu-liques from Jo-anns (purchased with coupon) to sew on that way I don't have to quilt blanket. I bind with fleece binding which can be purchased (again with Jo-anns coupon). Appliques can be your own design too, but whatever you like or my personal saying "whatever makes your hair fly back". As for a batting in a larger quilt, I like cotton only because that way it breaths with you when you sleep. Fleece is a polyester, after all and is a nylon/polyester that does not breath. This is my very own personal preference and opinion. Thank you for listening. I love all the posts and opinions and I drool over some of the quilts. What fabulous talent. I feel so humbled.