I use it in many applications because it is quick and needs no pins. I have made lots of small things like table runners, place mats, etc. I also used it in a queen size quilt without significant problems. I started fusing in the center and worked out. I used straight pins to help keep it straight. I used a basting stitch around the perimeter of the quilt after fusing it. Even though I could easily re-position it I did not need to. I would certainly use it again. It is soft after washing the finished quilt.

I've used Hobbs 80/20 fusible on a twin size quilt. It was okay, but I needed to iron small sections for it to work well. Probably my error in usage.

For a quilt as you go, it is much easier and less expensive to use Elmer's School glue to baste a 13.5" backing, a 13" batting (any type) and a 12.5" block together. Allow time to dry, and "quilt as desired". This method leaves you plenty of options for connecting the blocks.