I have a quilt made by my grandmother in probably the 1970's that has been washed and used (and used and washed...) with no problems. She made a log cabin using regular cottons for two sides and seersucker for the other two and it's fine. As far as stretching/ironing/shrinking goes, I have a favorite shirt from Land's End or LL Bean that's seersucker. I wash and iron it with no problems and have never noticed any shrinking or other issues.

I've used it several times, even as backing and have had no complaints so far, it washed well. DEB

I have made many memory quilts using all kinds of fabrics from people's clothes. If it's stretchy just be sure to stabilize the fabric.

Years ago I bought some pretty multi colored pastel searsucker fabric to make a summer weight robe, thinking well it's searsucker so it must be cool NOTTTT! It it really warm and probably because it is tightly woven. Anyway I didn't find it hard to work with reallky, but to me it is really warm and if that's what you want or need in a quilt it will probably be the fabric you might want to use.

I have made pillow cases from seersucker. I washes up so soft

The only issue we had was if you iron it, the little dimples don't really come back.
But it was soft and looked cute with the cotton. :)

I put some seersucker in a baby quilt and it was fine.

I love seersucker for clothes because it is so cool in the summer. But often seersucker comes in some wonderful stripes. I would use it in a quilt.

most seersucker is cotton or poly-cotton. Behaves just like any other cotton

I didn't have any "problems " as such, (made a QAYG for my GDD) but be careful with any pressing, it will go flat with a hot iron, ask me, as I know LOL!