Thanks to each person who offered suggestions :)
 

I truly appreciate it. Gives me the encouragement to keep trying :)

I can relate. With all those different sizes, you might have to add a few
sashings here and there to make them fit. It's easier if the blocks are 2, 4, 8, 16.
Or 3, 6, 12, 24. You could also group a few of the small blocks to make a
bigger block.

BTW, Pat Sloan has some videos where she shows how she puts her
odd blocks together. It doesn't have to be boring.

Have fun!

Thanks again!

Take pictures of each layout before you start rearranging

It seems like photos are more objective -

Thank you for asking this question and thanks to all the advice given. EasyPeezy - great suggestion to get all the pieces to divisible inches. That helps so much.

There are two books by Sharyn Craig, Great Sets and Setting Solutions that I have and refer to often.

I need to see things in color rather than using graph paper. I would decide on a generic size block, say 12" or 16" finished. Then I would group blocks together, perhaps by color or design, and set them together into 12" or 16" blocks. It might involve adding a neutral filler or skinny sashing in between. Or maybe fill in with some checkerboards or flying geese to get things up to size. Then I'd put the blocks together.

I make t-shirt quilts with different sized blocks. I start in the center with a focal point. I use my bed to lay them out.