What pattern would you use....
 

using layer cakes that is good for large prints?

Missouri Star's Double Slice Layer Cake pattern would be good for large prints.

http://www.youtube.com/watch?v=jxC-0T5lXw4

You could do a snowball block, that would really show off the large scale prints without having to cut them up !

I am working on 'charmed stars' right now. I am using charm packs and my finished block is 13.5 inches. It would be a HUGE block using a layer cake.
http://www.modabakeshop.com/2010/10/...ars-quilt.html

I like it! I don't even mind cutting the layer cake into the 5" squares.

Floating stars or shadowbox

Oh my goodness both of those patterns I want to try but I really like the stars too.