I've made lots and lots of baby quilts. Because new moms choose themes for their nurseries and because they all have different likes and dislikes in colors, I choose to make little "utility" quilts that can be used and abused and enjoyed by baby. I usually choose bright colors or nursery rhyme "themes" for my quilts. Sometimes I even throw in a little black and white because of baby's eyes. I usually add a card (or tell the mom) that this is NOT an heirloom quilt. It is a quilt to be used for practical purposes. They can throw them on the floor, on diaper changing tables, etc. Baby can SLEEP, PLAY, PEE, PUKE, OR POO on them. Then throw in the washer and dryer and it's good to go again.
The last baby quilt I made was for my mom and my sister's oncologist. It was a bright quilt made for 5" squares from my leftovers from other baby quilts. On my sister's last visit, her doctor told her how much they were enjoying the little quilt that can be thrown on the floor for baby to sleep or play.