I was making a batik quilt and all my quilting friends had me so spooked about sewing the batik that I changed my plan to hand piece. After making one block i was thinking...I am going to have to hand sew the binding. So I experimented, and it was fine to hand piece. My fabric was prewashed. Maybe that is what made hand sewing okay. The quilt I made was king size. So, my advice is try and then decide what works best for you.
Donna