I gave up a lot of things:
Guilt: at not having a clean house, done dishes, and a career.
Anger: at being disabled, went 'poof' when I started being creative again.
Frustration: at not being 'perfect' at sewing or any daily task. Perfection is up to God, and frankly, I'm not Heaven Material yet. ;)
Depression: Just the joy in creating something helps, even if its just a mess!