The quilting group I belong to is currently making quilts for an unwed mothers' pregnancy center. The patients earn points by going to dr's appts, etc. to spend in the "store" and buy quilts and other items with the points. We have also made approximately 120 quilts for an orphanage in Kenya and several for children in foster care.
Neonatal care units, childrens hospitals, hospice groups, the military and their families, domestic abuse shelters, unwed pregnancy centers, children's homes and their emergency receiving shelters and foster children are some places that would happily receive handmade quilts. Then there are foreign needs such as earthquake regions, etc.
Sorry if I didn't help you narrow down the possibilities. So many opportunities, so little time! (sigh)