Most definitely make reservations, Sisters is a small town of about 1000 people. When I went, we stayed in Bend OR, at a wonderful place right on the river. If you can get a bus trip into the town it works well, because parking can be very limited. It was 106 degrees when I went and long lines everywhere. It was great fun, so many beautiful quilts to see the heat was a royal pain, but I am still so happy I was able to go. My friends took a bus tour in from Portland. I was coming down from Yakima WA and wanted to spend the time in area.