My husband & I are both left handed. When he was a kid working in his Dad's farm machinery shop, the engines, tools, etc, all are designed for righties, so he learned to adapt.
When Mom taught me to crochet, knit, tat, cross stitch, embroider, I faced her & did the reverse of what Mom was doing. One gets used to doing things the oposite way.
It looks funny to me when I see my rightie Sis slice home-made bread - of course, she thinks I'm backwards!
If left is all I've ever known, it matters not in most things.
I did draw the line with scissors - the grooves on right-handed scissors hurt my fingers, so I have several sizes made for lefties now & love them.