We started full-timing 2 years ago and I have had no problem with quilting in a motorhome. I was asked how I did this so I posted pictures and what worked for me in my blog:
http://quiltincats.blogspot.com/2009_07_01_archive.html
Recently, we found a screen house with a floor. I have been using it quite a bit. My biggest problem - TIME! Setting up and breaking down. So I try to plan ahead the night before.