I did on a Janome 6500 but I think it would be possible on a regular full size machine too. I used Warm and Natural batting. Warm and Natural is low loft and it can be stitched 11 inches apart. It is a big job.
http://www.quiltingboard.com/t-94447-1.htm
http://www.quiltingboard.com/t-101630-1.htm