I did this queen quilt on my Singer Confidence Quilter:
http://www.quiltingboard.com/t-77903-1.htm
Always start in the center and work your way out to the corners then the edges inbetween. The challenge is in cramming half a quilt inside the throat of the machine. Don't roll it up, just kind of accordion it in there - a huge roll is much more difficult to deal with, believe it or not. Also, make sure you have plenty of table space behind your sewing machine - I got a small 2'x4' table from Walmart and it worked fine. I also moved my dining table alongside my left side where it butted up against my sewing table to accommodate the weight of the quilt. It's tricky, but it can be done.
Oh, and this was my first large quilt to be done, and my parents LOVE IT! They toted it around and showed everyone when they got it, even brought it with them when they traveled for Christmas to show it off. I was really proud! Good luck.