Don't think it has anything to do with being left or right handed. I have noticed that sometimes the top of the slots have a little burr on them that the cutter catches on. I get a sharp exacto knife and file off the burr and that takes care of the problem. Still have to hold the cutter straight up and down, no leaning to the side. Haven't tried a Dritz cutter but the Olfa with the automatic release can be switched over for left-handers. I went to that one when I knocked an open Olfa off onto my foot and cut the crud out of my big toe!!