In my experience, thread suitable for hand quilting always specifically says "suitable for hand quilting" or "hand quilting" somewhere on the label. Thread is manufactured by a weight designation. The LOWER the number the HEAVIER the thread. So a 35wt thread is much heavier than a 50wt thread. Most multipurpose threads are 50wt or 60wt and I prefer using a much heavier thread for handquilting. For Machine quilting I have used very lightweight threads, even silk which is 100wt (very fine!)
So for your handquilting project seek out a thread specfically made for handquilting. And if you really want your stitching to show go for something that is designated as a 35wt or 40wt minimum. One strand is all you need.