I made one of these in 2001- my Millenium Quilt with 2001 different fabrics. I cut and sorted fabrics by color. Then I laid out the pieces on a piece of fusible interfacing with 2" grid printed on it. When all pieces were arranged, I pressed it to fuse. To sew, I folded 2 rows together on a line, right sides together and sewed a 1/4" seam. When all rows in one direction were sewed, I folded and sewed the other direction. Somewhere in there, I clipped each intersection so the seams would fold one way or another. This made a really daunting project manageable