I travel with my cat to Florida each winter. She hates the trip. I use a large dog carrier and keep it in the back seat. I put a dish pan (Used only for this) of kitty litter in the cage with her and a small dish of food and another of water. I put a small bathroom mat on the floor of the carrier and I keep a harnass on her at all times. When I get to a motel and I'm in for the night, I let her out. I got some pills from the vet to help her relax, but they don't really work, so I talk to her a lot and tell her verything is fine. My voice seems to sooth her. It is a very painful 3 day trip for both of us, but the warm weather is worth it. Hope this helps.