My MollieSue had peed in the house for years, during the night, or then during the day when I got a job. She's a rescue muttly and had been abused in her previous life, so is skitterish at times. I jokingly told the vet about it while there for a different issue. He put her on antibiotics for just in case she had a uti, and also an anti-anxiety pill as he said sometimes they do it out of stress. She's not peed once in the house since, and it's been 2 months now! :) :)