I used to handquilt everything, and that is still my preferred method, but I never have enough time to do it anymore. I have had several projects (commissions) in the last year that would have been impossible to handquilt, even if the client had wanted it: T-shirt and heavily pieced and appliqued quilts!
To handquilt the size you mention, as my sole project but only in regular quilting time, would take me about 5 months. FMQ would take a week or two (I use my domestic sewing machine).
Alison