What ever organization you intent to donate to .. check there requirements in advance. Some are very particular as to size, fabrics , type of quilting etc.
Most nursing homes are not as fussy as project linus or quilts of valor. In addition, homeless shelters will take quilts made from poly and many infact prefer them as they are warmer than cotton. Depending on the weight of the poly , would depend then on if I used a batting or not. Many of the old double knits need no batting, especially if you use them for backing as well.