Dr. has me on methotrexate 2.5mg and I was on predsinone 5mg a day but I quit taking that now and take 8 methotrexate 1 time a week and shoulders and arms and hands feel fine. Sometimes my neck bothers me and I take a tylonel PM at bedtime and it is better in AM and for a week or two. I think is it sitting in this chair on computer too much sometimes.