BELIEVE ME WHEN I SAY: It CAN be done and it is a MOST wonderful feeling when finished. I made three 50 X 60 quilts for a lady from her mom's clothing. All kinds of fabric, thick, thin, in between. I just used very thin shirt interfacing, ironed it on, cut 12 x 12 squares and sewed them together. Put a 3 inch border around edge. Granted you'll have to go around collars and buttons when quilting , but the end result if fabulous, specially to the person you make it for. If I can do it, I'll post a picture of one of them. Now, they can be rather heavy, so make them smaller than queen size.