Sew Much More in Garden City! We went to Hilton Head last year and spent 2 days in Savannah. Bonnie, the owner of Sew Much More, and her staff were the most friendliest group I encountered in any of the shops I visited. When she found out that we were traveling with my 15 yo Pomeranian Toby, she insisted I bring him inside the shop and even took a picture with us!!!
We also went to Island Quilters which is in Hilton Head (if you make it that far out from Savannah). Nice selection and I did drop a good amount of cash in there as they had a fabulous markdown room.
We planned a detour off our main route from Indiana to Hilton Head to stop in Gastonia, NC at Mary Jo's. It was well worth the detour, depending on your route to Savannah. It is huge so if you go, budget yourself a good amount of time. I only had an hour and I missed a great deal of the store!!!
Enjoy Savannah! Take one of the horse drawn city tours; you will learn a lot about the history of Savannah and the architecture of the homes and buildings is just fabulous!! And go eat Macaroni & Cheese at Paula Deen's resteraunt, Lady & Sons - you won't be disappointed !!!