I prewash every piece of material. Small pieces go into a lingerie bag or 2 or 3. Nicotine odor is hard to get out. Depending on how large the smaller pieces are would depend on whether I wanted to fool with them or not. I would be insulted if someone made me a quilt and it smelled of smoke. That's me. If you can find some one who has not been around smoke in a while ask them to take a whiff. The slightest hint of smoke will be made stronger when it dries.