Yes it is possible. I spray basted my quilts and reinforced the edge and some places with a safety pin. I used Warm and Natural but I think it is a good idea to use something a little thinner like Hobbs 80/20. Support the quilt as well as you can by placing smaller tables or an ironing board next to the table you have the sewing machine on. I puddled the quilt and started from the center. I marked quilting lines with crayola washable markers. (Just besure not to iron it once it is marked and use lighter colors!) Start quilting from the center. If you can get the quilt puddled and to the center then you know you can do the whole quilt. I did quilt the quilts more lightly. That was an advantage from the Warm and Natural batting as it only needs to be quilted every 11 inches or so. It could also handle the pulling of the quilt under the sewing machine harp.