One of my earliest quilts was made this way, before I was informed by the All Knowing P.I.T.A. Quilt Police that is was a violation of some ridiculous and imaginary rule. It turned out quite nice and is my son's favorite quilt. It's warmer than his other quilt, which is flannel with W&N batting and muslin backing. The polar fleece is lightweight but warm, and drapes around him better. I had no problems at all quilting it on small, inexpensive Brother. I say go for it!