Assuming that things are very good - no wavy borders or "volcanoes" in the blocks and the backing is square - I would say about 6-8 hours. However, things seldom are "perfect", so there will usually be something somewhere that slows down the process, so perhaps another 2-3 hours for the "problems"... which means an average of 8-11 hours for me.
With that said, I do have a "real" job, and therefore do not stay at the machine for 8-11 hours straight. I may manage 2 hours in the evening when I get home from work, and sometimes (if hubby is a good boy and doesn't bother me) I can get 5 hours on a Saturday. So, overall, it may take me a week or more to finish a queen, with FMQ or pantographs.