I've often mixed flannels with regular cottons, they come out beautifully. I love the Woolies line of flannels They don't shrink much- I've never had one pill. They are ( good quality, fairly tightly woven) great flannels. I n prewash over & over again my flannels. Especially the good thick ones. I prewash once in warm water, short cycle, toss into the dryer on a regular cycle then remove them before they are over dried. They are so ( Huggable) coming out of the dryer!