I've used homespun multiple times with no problems. I'm often/usually, however, stitching it to a regularly woven cotton.
One of my projects has been in use and being washed for about 5 years, still looks good. (Is at my son/DiL's so I get to see it.)
As in the other advice, it does tend to be looser woven with thicker threads, but once washed and dried (on hot) I let them mix and match with my other scraps.