A few years ago my guild made a raffle quilt, all hand appliqued. A blue water soluble pen was used to mark the quilting lines. The quilt was hand quilted. It took about a year to finish. After the quilt was dried, some of the blue marks re appeared on the white background. Not all of them but enough to ruin the quilt. No amount of water removed the marks. The blue lines kept coming back after drying. A new quilt had to be made. We had the raffle the next year.