Hi Connie,
I also quilt on my domestic. Just finished a queen size Irish Chain. I used Marti Michell's method of quilting in sections. For this one I quilted entire center of quilt 70 x 90 first. Then added borders, more batting, more backing. It worked great for me! I would do it again. Am currently in the middle of a T-shirt quilt that I am going to do "quilt as you go" Am quilting individual blocks at this time and then I'm pretter sure I'm going to do the QAYG no hand sewing method, there's a great tute on this board. BUT I haven't done that yet so I can't give an opinion on that method.
Good Luck, Have Fun
peel