I quilt on my domestic too. I don't do fancy intricate feather wreaths or such but on large quilts I will quilt diagonally corner to corner or straight line and off set from the patterns of the blocks if the pattern is geometric. When in a hurry and if it fits the pattern of the blocks I will do wavy lines. (Great for quick baby quilts) When I do simple meandering on large or small quilts, I always mentally divide my quilt in quarters as mentioned by other posts. It makes the process so much easier, less manhandling of that large project under the needle.