I think it's Aurifil that recommends using their 28 wt. for hand quilting; I tried it once because I was trying to match many colors, but I didn't like it. It was constantly breaking/fraying off my needle (it's only 2-ply and it doesn't seem very strong to me). I prefer a regular hand quilting thread like Gutermann's. If you were doing big stitch or trying for a decorative effect, then I think the 28 wt. would be appropriate.