I'm not too fussy about the print being on grain or not. I can either cut with the print, or square-up from the fold. Unless it's a panel, it doesn't really matter. And I've found that I can mostly cut a panel by the print, and when I sew it in, it usually straightens out just fine.
I do want to use quality fabric and thread!
I am persnickety about removing threads when I un-pick, and about trimming thread ends as I sew. I'm also persnickety about pressing seams as I go.