I made a quilt out of 100% Scalamandre drapery fabric.
It was hard to hand quilt. I mean HARD, but it turned out nice and will not shrink or fade (I washed a piece).
It has a nice feel and is not too heavy or stiff.
The pattern was simple and the pieces large since the fabric has a very dense weave and large floral motif.
I would NOT do it again, though. My hands have not recovered...
If you machine quilt then I say go for it!