When I quilt on a DSM I quilt large quilts in sections. I use the Marti Michell book - http://www.amazon.com/Machine-Quilti...6008588&sr=8-1
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It's certainly NOT easy!!! One reason I have tops done but not quilted.
I am quilting a 106" x 106" quilt with high loft polyester batting. I turn my machine sideways so I have more room for my hands and just bunch 1/2 the quilt into the throat and work in 10" - 12" strip at a time all the way across one way and back the other way until I have the first 1/2 done. Then take the quilt out and turn it around and repeat. The first strip across is the most difficult. I tried rolling , but I find it much easier to work with the quilt just bunched. You have to stop often to reposition the quilt and smooth out an area to work on, but it really goes pretty fast if you are just meandering or stippling.
You can see my setup here http://www.quiltingboard.com/t-52581-1.htm