it's certainly okay to be a little bit selfish and take the larger room with bath for your dedicated craft space. Your guests don't care about the size of the room they sleep in, just that they get to spend some precious time with you! Have fun organizing the larger room to suit your needs - you'll be a much happier lady!

You live there full time, make it work for you. :) if not having a bathroom attached is a deal breaker for your guests, they should find somewhere else to stay.

1st How often DO you have Quests? if its really only 1 or 2 time a year I would Says So what if they have to go out to the Hall to go to the bathroom or Can you have a small door put into the wall between so the bathroom and the small quest Are connected? Then combine your crafty stuff.:)

Most of us remember that old adage about not saving our "nice" lingerie or sleep wear for another day; wear it now. So, use your room and don't save it for "nice". Guests usually don't stay more than a few days so don't worry if they have to peruse your shelves of fabric or your books, etc. They might find something interesting to look at. Enjoy your own space.

I agree with this very practical answer. I'd also add that in most average houses where we live, especially newer ones, 14 X 15 is a generous size for a guest room. You should be able to have a piece of furniture, such as an armoire or bookcase, that would attractively house some of your supplies, unless you have guests in there so often that it wouldn't be convenient to get in there when you need the stuff.

True true I've seen Some Living rooms that are only 14x15!!!

I would and don't keep a guest room. I live in a small house and barely have room for us. Our oldest Granddaughter almost 26 lives with us and has the past 7 years. She has the largest room (lots of stuff). When she moves that will be my sewing room. She is trying to get through college on her own and working. She is getting close. She goes to school nights and weekends. Had gotten wrong information before and that set her back a bit. I'm patiently waiting.
That being said I think you should use your house to the fullest for yourself and use it all. Let guest worry about themselves.

Compared to what your rooms are; mine are really tiny. One is about a 12 x12 and the other a little smaller. The smaller room has a full size bed and dresser in it and my small gracie frame. I almost made both of my rooms my sewing/office but my daughter and her family often spend at least one night every week or so. Plus, my bedroom is upstairs and sometimes I don't feel like going up the stairs, either due to being really tired or when my back or legs act up so it's good to have it. The other room is kind of crowded but I have room to do it all. My sewing table has the one end up against the wall in the center of the room and goes right out into the center of the room. Everything else is around it. The wall in front of it has the cubes from Walmart, the ones with 9 cubes each, I have 4 and they are stacked 2 high, some with canvas totes others not. I put pictures on the totes as to the contents or projects so I don't have to pull them out each time to see whats in them. I also have my small TV in one cube. Beside that is one of the tall wood look bookcases you can get from Office Max, etc. The center shelf doesn't move but the rest do. I went to HD and had them cut me more shelves so they are closer together and I could fold my fabric to fit each shelf and could separate the color and type of fabric better plus the stack isn't so tall that when you need something at the bottom it messes up the whole stack. On top of that I have the plastic zippered bags that my comforter came in which has Christmas fabric in and other fabric that I don't often need to get into but with the bags being clear I can easily see whats there. Under the bed in the other room I have put bed risers and long under the bed totes with my large pieces of fleece. My friend sent me boxes of it and I only have fleece in there so I won't forget whats there. Before I set up my bookshelves with my fabric I always forgot what I had. I wouldn't worry about an attached bathroom making the decision. None of my rooms have an attached bathroom, they are all out in the hall close to the rooms. You could always make one room for all of your fabric, cutting table ect and then set up your machines or even your backup machines in the guest room. Then if you have guest it wouldn't take much to get it ready. If you have a certain machine that you do most things on then keep that one in your sewing room so if you do have company you can still sew.

Use your wall space, like Ragamuffin suggested. Go up!

I would make a big decision about cleaning up scrapbooking & sewing. Combine the two together. Maybe add some cabinets & shelving on one end of the room for scrapbooking & the rest for your sewing. Shelving on the wall from top to bottom for fabric. This is what I did. On some walls I have cabinets below shelves.
Keep the guest room neat & clean, just for guests.