Enjoy it. You will love it. Do not be intimidated by the size of it or the exterior, which looks a wee bit grubby. The staff is friendly and very helpful. Go early especially if you are going on a sale day. The bolts often end up being driven around in carts, so you don't always get to see everything they have. Wear comfortable shoes. Bring water, eat a hearty meal before you go, and HAVE FUN!!
If you are in Vancouver, you might also check out The Quilter on NE Chaklov near Mill Plain and Art and Sewl on NE Evergreen. The second shop is small, has a live-in shop dog and does not carry a ton of fabric, but still a cute shop. The Quilter is a lovely shop too - bigger than Art & Sewl, and an easy stop off I-205 so you could hit it on your way to or from Fabric Depot. Have fun!