My sewing desk has three drawers on the right of the "L" shape and two large ones on the left. I further divided it up with boxes to organize the drawers into sections. Then there is a store bought white shelving unit that I placed on the corner of the L. I bought three fabric drawers to sit inside and to hold larger sewing things I use all the time. It has proven to work out great for me. I hate thing sitting out, so I only have out what I need at the time and the drawers being organized, they are easily found when I need them.
Before I had this set up I used a nice wooden sewing box. The lid closed tightly, so no dust on my tools. I live in high desert, so this is an everyday reality for me.