I've done super sized queen quilts on my DSMs. ... lots of them. It's certainly doable. If I might offer a couple of suggestions??
- Make sure you have tables or something to support your quilt on the left side of your work and in the back. Supporting the quilt makes a world of difference. Keeping your quilt from 'hanging' anywhere will keep the quilt easier to move around.
- I recently purchased a 'supreme slider' that fits on the bed of my machine and is so smooth that the quilt glides so easily as I'm quilting. I don't know why I didn't buy one of these sooner.... well, I do know. They are pricey. But, now I'm thinking of getting a larger one that will cover even more space. I was amazed at the difference.