Your blocks are great - I love the colours :D
It depends on what you are appliqueing.
You block design is quite detailed, and I personally think it would be a shame to 'hide' the design with applique covering it...but if you are considering an alternate applique block spacing them out, then its best to apply the applique at the block stage, but if you are adding a winding stem for instance that may cover a number of blocks then stitch your top together then add the applique before layering and quilting....thats how I did my sampler quilt, does this help??? :lol: :D